I have been running my Road6 at 46R and 44F cold pressure, and I believe this has contributed to a marked improvement in tyre life. I did this in consultation with a very good friend who is the adviser for the local Metzeler and Dunlop importers. As others have stated the pressure rise noted through a TPMS is significant, and much greater on the rear of my ST than on my other Road6-shod bikes (e.g. MT-10, VFR800). I asusme the weight and shrouded-by-panniers location plays a big part here.
The lower the starting pressure, the more tyre deflection there is which generates more heat and gives a greater pressure rise; this is why a comon failure mode for car tyres is to keep driving when they are going flat, which seriously overheats and eventually shreds the carcass. "GT" spec bike tyres use a stiffer construction which reduces this heat build-up to prolong tyre life. I can't say that I notice any difference in ride quality at higher pressures, and there's certainly no shortage of traction. Anything that you do that reduces the tyre temperature will be beneficial for mileage, but YMMV.
I might take a different tack if I lived somewhere seriously cold, but lucky me, I don't.