Mileage may or may not be a factor. Depends on the type of riding one does. Like I said, my commute is very hard on the bikes in general. I'm seldom cruising for more than 20 miles at a time, then when I'm lane splitting, I'm constantly on the clutch to go up or down. So at 116K, the '05 was ready for a new clutch. Now, take someone that doesn't commute and most of their riding is miles of non-stop and the only time the clutch is engaged is for takeoffs and landings. That clutch could last 200K.
Commuting like I do, I see the bikes get beat up pretty good. I really had a hard time keeping my '05 in pristine condition, just ask my wife...
Since getting the other bikes, I have see the '04#1, that I added 37K to, require oil seals along with the waterpump at 68K. The 2010 has actually been a good bike, knock on wood, but no major issues that weren't with the bike when I got it... the Wax Assembly for instance. The '04#2 seems to be a good workhorse, it has cosmetic issues, but mechanically seems to be okay, but I did replace all the coolant hoses on it. And when I begin to prepare it for sale, I'll go through and make sure all is well, except the cosmetic things aren't getting fixed.
So, like I also said, if I have to tear into something, like the throttlebody or waterpump, I'm going to take a look at all components exposed and decide if replacing is in order.
My suggestion is, if you are removing the waterpump on a bike with 100K on it, at least check the measurements of the clutch plates and springs. If you removed the throttlebody for some reason, check your hoses. That simple!